/* Detail info (structure / connection / receptor / target / drug) lives in
   the Details pane of the main panel, shown by the active detail tab (see
   .panel-tabs / .detail-tabs above); the .info-* content styles below are
   reused there. Each detail tab carries its own × close affordance. */
.info-title { font-size: 14px; font-weight: 600; margin: 0 0 8px; }
.info-route {
  font-size: 13px;
  color: var(--text);
  margin-bottom: 10px;
  display: flex;
  align-items: center;
  flex-wrap: wrap;
  gap: 4px;
}
.info-route .conn-dir { color: var(--muted); }
.info-meta {
  display: flex;
  align-items: center;
  gap: 8px;
  font-size: 12px;
  color: var(--muted);
  text-transform: capitalize;
  margin-bottom: 10px;
}
.info-desc {
  font-size: 13px;
  line-height: 1.45;
  color: var(--text);
  margin: 0 0 12px;
}
.info-connections h3,
.info-bindings h3,
.info-bindings > summary, /* a collapsed section's summary IS its heading */
.panel-sec > summary,
.panel-sec-empty > .panel-sec-head, /* an empty section: a summary look, no fold */
.info-locations h3 {
  font-size: 11px;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  color: var(--muted);
  margin: 0 0 var(--sp-m);
}
/* A heading's plain-language subtitle (panel/dom.js withSubtitle): its own line
   under the title, sentence case, inside the <summary> so it shows while folded. */
.section-sub {
  display: block;
  margin-top: 2px;
  font-size: 11px;
  font-weight: normal;
  text-transform: none;
  letter-spacing: normal;
  color: var(--muted);
  opacity: 0.85;
}
.info-bindings > summary:hover,
.panel-sec > summary:hover { color: var(--text); }
/* A folded detail-panel section (js/main.js foldSections): the open body sits
   one step in under its heading. */
.panel-sec { margin: 0 0 var(--sp-m); }
.panel-sec > .panel-sec-body { padding-left: var(--sp-indent); }
/* An empty section (panel/dom.js emptySection): its heading stays unfolded, the
   caret's room kept blank so it lines up with the folded ones, then one muted line. */
.panel-sec-empty > .panel-sec-head::before {
  content: "\25B8"; display: inline-block; margin-right: 6px; visibility: hidden;
}
.panel-sec-none { margin: 0; font-size: 12px; font-style: italic; color: var(--muted); }
.panel-sec.panel-sec-empty > .panel-sec-none { padding-left: var(--sp-indent); }
.info-connections ul,
.info-bindings ul,
.info-locations ul { list-style: none; margin: 0; padding: 0; }
/* Receptor classification facts: label / value rows. */
.info-facts {
  display: flex;
  flex-direction: column;
  gap: var(--sp-m);
  margin: 0 0 var(--sp-xl);
}
.info-fact { display: flex; gap: var(--sp-l); font-size: 12px; line-height: 1.4; }
.info-fact .fact-label { color: var(--muted); flex: 0 0 92px; }
.info-fact .fact-value {
  color: var(--text);
  display: flex;
  align-items: center;
  flex-wrap: wrap;
  gap: 6px;
  text-transform: capitalize;
}
/* A clickable fact value (a drug's Class / Nomenclature): runs a search.
   The connection panel's route endpoints share the same link styling. */
.fact-link,
.conn-endpoint {
  background: none;
  border: none;
  padding: 0;
  font: inherit;
  color: var(--accent-bright);
  cursor: pointer;
  text-decoration: underline;
  text-underline-offset: 2px;
  text-align: left;
}
.fact-link:hover,
.conn-endpoint:hover { color: var(--accent-light); }
/* A muted trailing note on a fact row (e.g. flagging a non-standard
   nomenclature). `text-transform: none` overrides the row's capitalize. */
.info-fact .fact-note {
  color: var(--muted);
  font-style: italic;
  text-transform: none;
}
/* A drug's regulatory-history rows (js/drug-history.js): prose values, so not
   capitalized; a market withdrawal reads in caution ink. */
.info-fact.fact-history .fact-value { text-transform: none; }
.info-fact.fact-warning .fact-value { color: var(--sem-caution); }
/* One withdrawal node in a grouped row: its country, then its own pill. */
.info-fact .fact-place { display: inline-flex; align-items: center; gap: 4px; white-space: nowrap; }
/* Receptor "found in" region list. Each row is name + its own expression
   provenance pill, pushed to the right (the claim "this receptor is expressed
   here" is graded per region). */
.info-locations { margin-top: 4px; }
.info-locations li {
  display: flex;
  align-items: center;
  gap: 6px;
  font-size: 12px;
  line-height: 1.5;
  color: var(--text);
}
/* The name only takes the width it needs so its provenance pill sits right
   beside it (more legible than stranding the pill at the far panel edge). */
.info-locations .loc-name { flex: 0 1 auto; min-width: 0; }
/* Non-human expression flag ("· rat"): amber, same token as the Ki chip's
   non-human tint, so a claim checked in animal (not human) tissue is visible
   without hovering the pill. */
.info-locations .loc-species {
  flex: 0 0 auto;
  font-size: 10px;
  color: var(--sem-amber);
  white-space: nowrap;
  cursor: default;
}
/* Expression density per region (Allen mRNA), when the owner carries a measured
   profile. The caption + its grade pill sit once above the rows because the
   profile is ONE claim; only the value varies per row. */
.info-locations .loc-density-caption {
  display: flex;
  align-items: center;
  gap: 6px;
  margin: 6px 0 2px;
  font-size: 11px;
  color: var(--muted);
  cursor: help;
}
.info-locations .loc-density-agree {
  font-size: 10px;
  color: var(--muted);
  opacity: 0.85;
  white-space: nowrap;
}
/* Per-row bar + signed z. The bar is scaled against this owner's own strongest
   region (a z is only comparable within one gene), so it reads as "more here
   than there", never as an absolute quantity. */
.info-locations .loc-density {
  flex: 0 0 auto;
  display: flex;
  align-items: center;
  gap: 4px;
  margin-left: auto;
  cursor: help;
}
.info-locations .loc-density-bar {
  width: 34px;
  height: 4px;
  border-radius: 2px;
  background: rgba(var(--ink), 0.12);
  background-image: linear-gradient(var(--accent-bright), var(--accent-bright));
  background-repeat: no-repeat;
  background-size: var(--fill, 0%) 100%;
}
.info-locations .loc-density-z {
  font-size: 10px;
  font-variant-numeric: tabular-nums;
  color: var(--muted);
  min-width: 30px;
  text-align: right;
}
/* A region row that resolves to a modeled structure jumps to it on click. */
.info-locations li.clickable { cursor: pointer; }
.info-locations li.clickable:hover { color: var(--accent-bright); }
/* receptor_effect rows (BETA): "<effect>  <mode>" + the node's pill on a
   receptor / target panel; on a drug panel, one "could cause" lead line, then per effect (or per receptor) one
   "via" chip per binding (jumps to the target) with that effect node's pill. */
.info-effects .eff-mode { font-size: 10px; color: var(--muted); white-space: nowrap; }
.info-effects li.eff-row { flex-wrap: wrap; align-items: baseline; }
.info-effects .workup-cond { font-style: italic; opacity: 0.75; font-size: 0.92em; }
.info-effects .eff-via { display: flex; flex-wrap: wrap; gap: 2px 10px; flex: 1 1 100%; padding-left: 10px; }
.info-effects .eff-via-item { display: inline-flex; align-items: center; gap: 4px; font-size: 11px; }
.info-effects .eff-chip {
  background: none; border: none; padding: 0; font: inherit;
  color: var(--accent-bright); cursor: pointer; text-align: left;
}
.info-effects .eff-chip:hover { color: var(--accent-light); }
/* The compound a derived row's binding comes from (the drug or one of its active
   metabolites), shown only when a readout mixes them: muted, after the chip text.
   Also on the Pharmacodynamics: net neurotransmission terms. */
.eff-from {
  margin-left: var(--sp-s); padding: 0 var(--sp-s); border-radius: 3px;
  font-size: 10px; color: var(--muted); background: rgba(var(--ink), 0.06);
}
/* A row head that opens another panel (an effect, a drug): see linkName. */
.info-effects .eff-link { cursor: pointer; }
/* Drug panel's predicted effects: the one conditional lead line over the list, and each
   binding's compact Ki (the binding profile's median). */
.info-effects .eff-lead { margin: 0 0 4px; font-size: 12px; font-style: italic; color: var(--muted); }
.info-effects .eff-ki { font-size: 10px; color: var(--muted); white-space: nowrap; }
.info-effects .eff-link:hover { color: var(--accent-light); text-decoration: underline; }
.info-effects .eff-chip:disabled { color: var(--muted); cursor: default; }
/* receptor_release_modulation rows (BETA): the site line ("heteroreceptor on
   GABA interneurons in VTA") wraps under the claim, like the drug-panel via chips. */
.info-effects .eff-site { white-space: normal; flex: 1 1 100%; padding-left: 10px; }
/* receptor_demographic rows (BETA): the direction chip ("↓ Age") before the sentence. */
.info-effects .demog-chip {
  flex: none; font-size: 10px; padding: 0 5px; border-radius: 8px; white-space: nowrap;
  border: 1px solid rgba(var(--ink), 0.2); color: var(--accent-light);
}
/* receptor_variant rows (ClinPGx #20): a sub-heading per variant (or per target
   on a drug panel), then "[Level 3 · low] may be associated with ..." + pill,
   and a muted phenotype / population / ClinPGx line wrapping under it. */
.info-variants .var-name { margin: 9px 0 2px; font-size: 11px; font-weight: 600;
  text-transform: none; letter-spacing: normal; /* not the .panel-subsec > h4 title look */
  color: var(--accent-light); overflow-wrap: anywhere; }
.info-variants li.var-row { flex-wrap: wrap; align-items: baseline; margin-bottom: 3px; }
.info-variants .var-level {
  flex: none; font-size: 10px; padding: 0 5px; border-radius: 8px; white-space: nowrap;
  border: 1px solid rgba(var(--ink), 0.2); color: rgba(var(--ink), 0.75); cursor: help;
}
.info-variants .var-meta { flex: 1 1 100%; padding-left: 10px; font-size: 10px;
  color: var(--muted); }
.info-variants .var-meta a { color: var(--accent-bright); }
.info-variants .var-target {
  background: none; border: none; padding: 0; font: inherit;
  color: var(--accent-bright); cursor: pointer; text-align: left;
}
.info-variants .var-target:disabled { color: var(--muted); cursor: default; }
/* Anatomical-group sub-headings inside the "Regional distribution" list (one per group, in
   the Structures-legend order): a level below the section's h3, with top space
   so each group reads as its own block (which also spreads the pills apart). */
.info-locations .loc-groups { display: flex; flex-direction: column; }
.info-locations .loc-group-label {
  font-size: 10px;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: var(--accent-light);
  margin: 9px 0 2px;
}
.info-locations .loc-group-label:first-child { margin-top: 0; }
/* The "Throughout the brain" line for a ubiquitous receptor carries its own
   grade pill (one expression claim), so lay it out like a location row. */
.info-desc-pilled { display: flex; align-items: center; gap: 6px; }